What is wrong with my family?

I have been married for 6 years to a wonderful woman who loves me very much. But my family makes her feel bad, and I understand why she feels that way. Every girlfriend, male friend, teacher, or neighbor I have had over the years, once meeting my family (Mother, and Aunts) our relationship fell apart. I am very tender hearted, so sometimes I am impervious to problems. Is it possible to still have a relationship with them and still have the others? My wife tolerates them because of her love for me, but I don't know how to carry on from here and be respectful to my family. They are not going to change. Most of my family has been treated for a mental disorder, and some of the doctors has labeled them socially illiterate. Sometimes I feel that I should isolate myself from them, I try to limit my time with them, I can tolerate them but other normal people cannot.